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试剂描述： 产品名称：L-trans-Pyrrolidine -2,4-dicarboxylic acid 产品别名：L-反式-烷-2,4-二羧酸 CAS号：64769-66-0 英文别名：(2S,4R)-pyrrolidine-2,4-dicarboxylic acid 分子量：159.1 分子式：C6H9NO4 纯度：98% 外观：见爱必信官网 保存方法：Store at room temperature 描述：L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-PDC is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-PDC has a correlated effect of inducing neuronal Ca2+ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-PDC for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5. 应用：An inhibitor of the glutamate transporter EAAT 产品信息订购：
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