D-erythro-MAPP,N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide,143492-38-0

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试剂描述：

产品名称：D-erythro-MAPP

产品别名：N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide

CAS号：143492-38-0

英文别名：N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide

分子量：361.6

分子式：C₂₃H₃₉NO₂

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：D-erythro-MAPP is a synthetic analog of ceramide. Shown to selectively inhibit ASAH/APHC (alkaline ceramidase) both in vitro and in HL-60 cells (IC₅₀ = 1-5 μM for ASAH/APHC (alkaline ceramidase) versus IC₅₀ > 500 μM for acid ceramidase). D-erythro-MAPP’s inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breackdown of ceramide to sphingosine.

应用：A selective alkaline ceramidase inhibitor

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