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Clozapine-d8,Clozapine-d8,5786-21-0(unlabeled)

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    试剂描述:

    产品名称:Clozapine-d8

    产品别名:Liponex-d8

    CAS号:5786-21-0(unlabeled)

    英文别名:Liponex-d8

    分子量:334.87

    分子式:C18H11D8ClN4

    纯度:≥98%

    外观:见爱必信官网

    保存方法:Store at -20° C

    描述:Clozapine-d8 is a deuterium-labeled version of the compound Clozapine . Clozapine is noted to bind preferentially to D4DR (D4-dopamine) and SR-2 (5HT2-serotonin receptors) and acts as a weak D1 and D2 antagonist. Clozapine is also reported to bind with the SR-2 (5HT2), SR-6 (5HT6) and SR-7 (5HT7 receptors). Two major metabolites of Clozapine are reported to be N-Desmethyl Clozapine (labeled compound; ) and Clozapine N-oxide . Additionally, reversed-phase HPLC has been reported as a method of identification of Clozapine and its two major metabolites. In studies investigating the induction of neutrophil apoptosis in rabbits by oxidation of Clozapine into reactive nitrenium ion, it was noted that Clozapine increased the rate of neutrophil release from bone marrow while also affecting the neutrophil half-life in the peripheral blood stream of rabbits.

    应用:A deuterium-labeled version of Clozapine, a selective compound for D4-dopamine and 5HT2 serotonin receptors

    产品信息订购:

      产品货号   产品名称   规格 价格 大包装及货期
      abs42015713   Clozapine-d8   1mg  2750   立即咨询

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