Bisindolylmaleimide VIII,acetic acid,3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione,138516-31-1

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试剂描述：

产品名称：Bisindolylmaleimide VIII

产品别名：Ro 31-7549 acetate

CAS号：138516-31-1

英文别名：Ro 31-7549 acetate

分子量：458.6

分子式：C₂₄H₂₂N₄O₂•C₂H₄O₂

纯度：≥98%

外观：Crystalline

保存方法：Store at -20° C

描述：Bisindolylmaleimide VIII is a selective PKC (protein kinase C) inhibitor, with observed binding activity to dystrophia myotonica protein kinase (DMPK). Bisindolylmaleimide VIII is suggested as being slightly more specific for PKC α over PKC β, PKC γ, and PKC ε isozymes (IC₅₀ = 53, 195, 213, and 275 respectively). The compound has been shown to improve DR5-mediated apoptosis through the MKK4/JNK/p38 kinase. When bisindolylmaleimide VIII is combined with TRA-8 it can activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase. Studies have shown that bisindolylmaleimide VIII enhance Fas-mediated apoptosis in both human astrocytoma 1321N1 cells and in Molt-4T cells.

应用：A selective PKC inhibitor

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