AAL-993,2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzami de,269390-77-4

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产品名称：AAL-993

产品别名：VEGFR Tyrosine Kinase Inhibitor VI; 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide

CAS号：269390-77-4

英文别名：VEGFR Tyrosine Kinase Inhibitor VI; 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide

分子量：371.36

分子式：C₂₀H₁₆N₃OF₃

纯度：≥98%

外观：见爱必信官网

保存方法：Store at room temperature

描述：AAL-993 is a highly potent inhibitor of Flt-1 (VEGFR-1), Flk-1 (VEGFR-2) and Flt-4 (VEGFR-3) (IC50=130nM, IC50=23nM and IC50=18nM respectively). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and c-Fms-CSF-1R (CSF-1R) (380nM). AAL-993 shows no activity towards other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. An X-ray crystal structure of AAL-993 complexed with the catalytic domain of diphosphorylated VEGFR-2 indicates that this molecule binds to an inactive conformation of the protein.

应用：A cell permeable inhibitor of VEGFR-1 (Flt-1), VEGFR-2 (Flk-1) and VEGFR-3 (Flt-4)

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