Trimipramine Maleate,521-78-8

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产品名称：Trimipramine Maleate

产品别名：马来酸三甲丙咪嗪

英文别名：Trimipramine Maleate

靶点：5-HT Receptor

CAS：521-78-8

纯度：>98%

外观：白色粉末

保存方法：-20°C

描述：

Trimipramine Maleate is a serotonin transport blocker that also blocks norepinephrine uptake. Trimipramine maleate has been used to develop chiral separation methods using capillary electrophoresis.

溶解性：DMSO : ≥ 31 mg/mL

体外研究：

Trimipramine displays much higher affinity for 5-HT₂ than for 5-HT_1C receptors.

体内研究：

The chronic administration of Trimipramine (5 mg/kg/day), as delivered by the osmotic minipump in 14 days produce significant increases in the regional concentration of 5-HT. The increases are highest in the frontal cortex and the hippocampus, followed by the olfactory tubercles and the hypothalamus. The Trimipramine treatment also produces marked increases in brain 5-HIAA concentrations ranging from 63% in the hippocampus to 25% in the nucleus accumbens with intermediate values for the hypothalamus, olfactory tubercles, frontal cortex and nucleus accumbens. Trimipramine treatment produces significant increases in DA concentrations in the nucleus accumbens, striaturn, and olfactory tubercles reaching 43, 21 and 11% respectively. Chronic administration of Trimipramine produces a marked reduction in the number of frontal cortex 5-HT₂ and striatal DA D₂ receptors. The chronic administration of Trimipramine produces an increase in the brain regional level of monoamines and metabolites indicating a greater synthesis rate for DA and 5-HT coinciding with an adaptive down regulation of 5-HT₂ and DA D₂ receptors.

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