Diclofenac Potassium,15307-81-0

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产品名称：Diclofenac Potassium

产品别名：双氯芬酸钾

英文别名：Diclofenac Potassium

靶点：COX

CAS：15307-81-0

纯度：>98%

外观：白色至微黄色的结晶性粉末

保存方法：-20°C 冷藏长期储存,常温运输及临时存放

描述：

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

溶解性：DMSO ：64 mg/mL (191.5 mM)
Water ：10 mg/mL (29.91 mM)

体外研究：

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

体内研究：

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