Deltarasin hydrochloride,1440898-82-7；1613404-76-4

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产品名称：Deltarasin hydrochloride

产品别名：见爱必信官网

英文别名：Deltarasin hydrochloride

靶点：PDEδ

CAS：1440898-82-7；1613404-76-4

纯度：98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ. 

溶解性：DMSO : ≥ 52 mg/mL (81.22 mM)
H2O : 50 mg/mL (78.10 mM; Need ultrasonic)

体外研究：

In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.

体内研究：Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.

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