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YZ剂描述： 产品名称：Ellipticine 产品别名：椭圆玫瑰树碱 英文别名：CCG-36483;CCG36483;CCG 36483;BRN-0221300;BRN0221300;BRN 0221300;DB-052047;K00071;LP00531;LS-133282;NSC 71795;NSC71795;NSC-71795;TCMDC-125546;VZ29809. elliptecine;ellipticine;Elliptisine 靶点：Topoisomerase CAS：519-23-3 纯度：＞98% 外观：Powder 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. 溶解性：DMSO : 5.8 mg/mL 体外研究： Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts. 体内研究： Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795). 产品信息订购：
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