LDN-212854,1432597-26-6

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产品名称：LDN-212854

产品别名：BMP Inhibitor III,LDN212854,LDN 212854

英文别名：BMP Inhibitor III;LDN212854;LDN 212854

靶点：ALK2 ,ALK1 ,ALK3 ,ALK4 ,ALK5

CAS：1432597-26-6

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.

溶解性：DMSO81 mg/mL warmed (199.27 mM)

体外研究：

In myofibroblast C2C12 cells, LDN-212854 exhibits greater selectivity for BMP6- versus BMP4-induced osteogenic differentiation.

体内研究：LDN-212854 (6 mg/kg, i.p.) effectively neutralize ALK2 signaling in vivo, and potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.

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