Memantine hydrochloride,41100-52-1

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YZ剂描述：

产品名称：Memantine hydrochloride

产品别名：盐酸美金刚胺

英文别名：Memantine hydrochloride

靶点：Cytochrome P450

CAS：41100-52-1

纯度：>98%

外观：白色结晶性粉末

保存方法：-20°C

描述：

Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with K_i of 0.51 nM and 94.9 μM, respectively.

溶解性：Ethanol ：40 mg/mL (185.4 mM)
DMSO ：40 mg/mL (185.4 mM)
Water ：28 mg/mL (129.8 mM)

体外研究：

Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC₅₀) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1.

体内研究：

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