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YZ剂描述： 产品名称：Elacestrant dihydrochloride 产品别名：见爱必信官网 英文别名：Elacestrant dihydrochloride 靶点：Estrogen Receptor_ERR CAS：1349723-93-8 纯度：见爱必信官网 外观：见爱必信官网 保存方法：见爱必信官网 描述：Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. 溶解性：DMSO: 17.6 mg/mL; H2O 体外研究： RAD1901 selectively binds to and degrades the ER and is a potent antagonist of ER-positive breast cancer cell proliferation. RAD1901 treatment exhibits dose-dependent inhibition of ERα expression, with an EC50 of 0.6 nM. Treatment of ER-positive MCF-7 cells with E2 results in a potent and dose-dependent increase in proliferation, with an EC50 of 4 pM. Treatment of cells with RAD1901 in the presence of 10 pM E2 resultsin a dose-dependent decrease in proliferation, with an IC50 value of 4.2 nM. 体内研究：RAD1901 produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models. RAD1901-treated animals survived longer than those treated with either control or fulvestrant. RAD1901 preserves ovariectomy-induced bone loss and preventes the uterotropic effects of E2. 产品信息订购：
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