Pravastatin sodium,81131-70-6

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YZ剂描述：

产品名称：Pravastatin sodium

产品别名：普伐他汀钠

英文别名：Pravastatin sodium

靶点：HMG-CoA reductase

CAS：81131-70-6

纯度：＞98%

外观：白色粉末

保存方法：Store at -20°C

描述：

Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.

溶解性：DMSO : 44.7 mg/mL (100 mM)
water : 44.7 mg/mL (100 mM)

体外研究：

Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC. Pravastatin produces relaxation of isolated aortic rings, with maximum vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin ( Pravastatin results in a dose-dependent inhibition of macrophage cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines. Small concentrations of pravastatin ( Pravastatin (

体内研究：Pravastatin (40 mg, single dose) causes a reduction in cholesterol synthesis in human monocyte derived macrophages by 62% in healthy subjects and 47% in hypercholesterolaemic patients. Pravastatin (40 mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis and a 57% increase in LDL degradation in hypercholesterolaemic patients. Pravastatin (30 mg/kg/d) results in decreased length of the dystrophic lesions by 34% and recovery of muscular structure in Male Wistar rats receiving irradiation, associated with decreased CCN2 level.

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