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YZ剂描述： 产品名称：Eflornithine hydrochloride Monohydrate 产品别名：依氟鸟氨酸盐酸盐一水合物 英文别名：DFMO hydrochloride hydrate;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate;α-difluoromethylornithine hydrochloride hydrate 靶点：Orn decarboxylase CAS：96020-91-6 纯度：＞98% 外观：白色粉末 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： Eflornithine hydrochloride, hydrate (DFMO; MDL-71782) is a drug found to be effective in the treatment of facial hirsutism. 溶解性：Water : 43 mg/mL (181.7 mM) 体外研究： When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur. 体内研究： Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension. 产品信息订购：
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