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Triamcinolone hexacetonide,5611-51-8

产品信息
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    YZ剂描述:

    产品名称:Triamcinolone hexacetonide

    产品别名:见爱必信官网

    英文别名:Triamcinolone hexacetonide

    靶点:Others

    CAS:5611-51-8

    纯度:98%

    外观:见爱必信官网

    保存方法:store at -20℃ for one year(Powder)

    描述:Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases.

    溶解性:

    In Vitro: 

    DMSO : 41.67 mg/mL (78.23 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    ConcentrationSolventMass1 mg5 mg10 mg
    1 mM1.8774 mL9.3872 mL18.7744 mL
    5 mM0.3755 mL1.8774 mL3.7549 mL
    10 mM0.1877 mL0.9387 mL1.8774 mL
    *请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
    In Vivo:

    请根据您的实验动物和给YF式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂(为保证实验结果的可靠性,体内实验的工作
    液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

    • 1.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

    *

    体外研究:

    体内研究:

    Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration.

    产品信息订购:

      产品货号   产品名称   规格 价格 大包装及货期
      abs822335   Triamcinolone hexacetonide   5mg  3600   立即咨询

    产品更多信息请进入爱必信网站咨询

    温馨提示:不可用于临床ZL。
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