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CDN1163,892711-75-0

产品信息

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    YZ剂描述：

    产品名称：CDN1163

    产品别名：见爱必信官网

    英文别名：CDN1163

    靶点：SERCA

    CAS：892711-75-0

    纯度：98%

    外观：见爱必信官网

    保存方法：store at -20℃ for one year（Powder）

    描述：CDN1163 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator.

    溶解性：

    In Vitro: 

    DMSO : 50 mg/mL (156.06 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    ConcentrationSolventMass1 mg5 mg10 mg
    1 mM3.1212 mL15.6060 mL31.2120 mL
    5 mM0.6242 mL3.1212 mL6.2424 mL
    10 mM0.3121 mL1.5606 mL3.1212 mL
    *请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。
    In Vivo:

    请根据您的实验动物和给YF式选择适当的溶解方案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的工作
    液，建议您现用现配，当天使用；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比)：

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (7.80 mM); Suspended solution; Need ultrasonic

    • 3.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

    *

    体外研究：

    CDN1163 (5.5-25 mM; 0-8 hours; rat cardiac myocyte cells) treatment reduces high glucose-induced resistin and nuclear NFATc expression and increases the phosphorylation of AMPKα in a time-dependent manner.

    Western Blot Analysis

    Cell Line:Rat cardiac myocyte cells (H9c2)
    Concentration:5.5 mM, 25 mM
    Incubation Time:0 hour, 4 hours, 8 hours
    Result:High glucose-induced resistin and nuclear NFATc expression were significantly reduced. The phosphorylation of AMPKα is increased in a time-dependent manner.

    体内研究：

    CDN1163 (50 mg/kg; intraperitoneal injection; for 5 days; male ob/ob mice and lean ob/+ mice) increases SERCA2 Ca2+-ATPase activity, decreases endoplasmic reticulum (ER) stress-induced cell death in vitro and improves liver Ca2+ transport activity. CDN1163 reduces blood glucose levels and improves metabolic parameters and gluconeogenic gene expression, reverses hepatic steatosis, inhibits ER stress and ER stress-induced apoptosis, and improves mitochondrial efficiency in ob/ob mice in vivo.

    Animal Model:Male 8-10-week old ob/ob mice and lean ob/+ mice
    Dosage:50 mg/kg
    Administration:Intraperitoneal injection; for 5 days
    Result:Markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis but did not alter glucose levels or body weight. Increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose tissue and reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis, possibly through SERCA2-mediated activation of AMP-activated protein kinase pathway.

    产品信息订购：

      产品货号   产品名称   规格 价格 大包装及货期
      abs822948   CDN1163   5mg  924   立即咨询

    产品更多信息请进入爱必信网站咨询

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