Salinomycin,53003-10-4

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产品名称：Salinomycin

产品别名：盐霉素

英文别名：Salinomycin

靶点：Bacterial

CAS：53003-10-4

纯度：98%

外观：白色或类白色固体

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways

溶解性：DMSO : ≥ 36.7 mg/mL (48.87 mM)

体外研究：

Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.

体内研究：LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.).

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