Ras Inhibitory Peptide,159088-48-9

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产品名称：Ras Inhibitory Peptide

产品别名：​Sos SH3 Domain Inhibitor​

英文别名：​Sos SH3 Domain Inhibitor​

靶点：Others

CAS：159088-48-9

纯度：≥95%

外观：Lyophilized powder

保存方法：Store at -20℃

描述：

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.

溶解性：Soluble in water.

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体内研究：

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