1-Naphthyl PP1 hydrochloride,956025-47-1

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产品名称：1-Naphthyl PP1 hydrochloride

产品别名：1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

英文别名：1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3;4-d]pyriMidin-4-aMine hydrochloride;1-NA-PP 1 hydrochloride

靶点：Src

CAS：956025-47-1

纯度：＞98%

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保存方法：-20°C Freezer

描述：

 1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases, including v-Src and c-Fyn, tyrosine kinase c-Abl and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. It was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. It was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest.

溶解性：DMSO: ≥ 73 mg/mL

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体内研究：

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