N6-methyladenosine,1867-73-8

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YZ剂描述：

产品名称：N6-methyladenosine

产品别名：N6-甲基腺苷

英文别名：6-Methyladenosine;N-Methyladenosine

靶点：Others

CAS：1867-73-8

纯度：0.99

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

N6-methyladenosine (m6A)是碱基修饰的腺苷类似物，在天然RNAs中作为稀有核苷。N6-methyladenosine(m6A)是mRNA的第五种碱基

溶解性：DMSO : 56 mg/mL (199.09 mM)
Ethanol : 2 mg/mL (7.11 mM)
Water : 14 mg/mL (49.77 mM)

体外研究：

N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes.

体内研究：LD50: Mice >1g/kg (i.g.).

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