CCT251921,1607837-31-9
- 品牌：absin
- 型号：abs814401
- 产地：中国
- 供应商：爱必信(上海)生物科技有限公司
- 供应商报价：￥8550
- 标签：CCT251921,1607837-31-9、CCT251921,1607837-31-9价格、CCT251921,1607837-31-9厂家、CCT-251921,CCT 251921、Absin、爱必信(上海)生物科技有限公司
产品库
公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
YZ剂描述： 产品名称：CCT251921 产品别名：CCT-251921,CCT 251921 英文别名：CCT-251921;CCT 251921 靶点：CDK CAS：1607837-31-9 纯度：>98% 外观：Powder 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述：CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). 溶解性： In Vitro: DMSO : ≥ 28 mg/mL (68.14 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
*请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。 体外研究： CCT-251921 has acceptable aqueous solubility and demonstrates minimal activity when tested in a panel of 55 receptors, ion channels, and enzymes at 1 μM and in a panel of 279 kinases; weak inhibition of CYPs is observed. CCT-251921 demonstrates potent inhibition of reporter-based readouts measuring basal WNT pathway activity in human cancer cell lines that have constitutively activated WNT pathway signaling: LS174T (β-catenin mutant), SW480 and Colo205 (APC mutant) or PA-1 human teratocarcinoma cells that are WNT ligand dependent. 体内研究： CCT-251921 shows improved oral pharmacokinetics and pharmaceutical properties in order to facilitate further evaluation of CDK8/19 pharmacology and progression into preclinical efficacy and safety studies. In APC-mutant SW620 human colorectal carcinoma xenograft model, CCT-251921 treatment reduces mice tumor weight (54.2%) at day 15. The inhibition of STAT1SER727 phosphorylation is maintained for more than 6 h after the last dose. 产品信息订购：
产品更多信息请进入爱必信网站咨询 |
