Riociguat (BAY 63-2521),625115-55-1

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产品名称：Riociguat (BAY 63-2521)

产品别名：N-[4,6-二氨基-2-[1-[(2-基)甲基]-1H-吡唑并[3,4-b]吡啶-3-基]-5-嘧啶基]-N-甲基氨基甲酸甲酯

英文别名：Riociguat

靶点：guanylate cyclase

CAS：625115-55-1

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外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：Riociguat (BAY 63-2521) is an oral soluble <b>guanylate cyclase (GC)</b> stimulator, used in the treatment of ipulmonary hypertension.

溶解性：体外:
DMSO 84mg/mL(198.85mM)
Water <1mg/mL
Ethanol <1mg/mL

体外研究：

BAY 63-2521 stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes.

体内研究：In chronic treatment of hypoxic mice and MCT-injected rats, Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature.

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