TOS-ARG-OME HCl,1784-03-8
- 品牌：absin
- 型号：abs817354
- 产地：中国
- 供应商：爱必信(上海)生物科技有限公司
- 供应商报价：￥350
- 标签：TOS-ARG-OME HCl,1784-03-8、TOS-ARG-OME HCl,1784-03-8价格、TOS-ARG-OME HCl,1784-03-8厂家、TOS-ARG-OME hydrochloride；NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐、Absin、爱必信(上海)生物科技有限公司
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YZ剂描述： 产品名称：TOS-ARG-OME HCl 产品别名：NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐 英文别名：TOS-ARG-OME hydrochloride 靶点：APC CAS：1784-03-8 纯度：＞98% 外观：白色粉末 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： TOS-ARG-OME hydrochloride is a kind od amino acid derivatives. 溶解性：DMSO > 10 mM 体外研究： TAME shows inhibitory effect on APC activation when added to mitotic Xenopus extract. TAME (1-200 μM) inhibits Cdc20 association with mitotic APC and also inhibits Cdh1 association with interphase APC. TAME significantly inhibits crosslinking of the IR peptide to Cdc27 and Cdc16 but only slightly reduces crosslinking to Cdc23 and Apc7 at 20 µM; TAME strongly inhibits crosslinking to all APC subunits at 200 µM. TAME also inhibits binding of wild type Cdc20 to the APC, but not binding of a ΔIR mutant. TAME (200 μM) induces Cdc20 dissociation from the APC in mitotic Xenopus extract calls for APC-dependent ubiquitination. TAME induces Cdc20 dissociation from the APC by promoting Cdc20 ubiquitination, but the dissociation can be suppresses by Cyclin B1. TAME terminates cyclin B1 ubiquitination prematurely. TAME interacts with ATP by β and γ phosphate and the adenine ring of ATP. TAME in combination with the Mg(II) ion accelerates the ATP hydrolysis process. 体内研究： 产品信息订购：
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