Bufalin,465-21-4

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YZ剂描述：

产品名称：Bufalin

产品别名：蟾毒灵

英文别名：Bufalin

靶点：Steroids

CAS：465-21-4

纯度：＞98%

外观：白色结晶粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in cancer cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

溶解性：10 mM in DMSO

体外研究：

Bufalin (0, 1, 2, 4 μM for 48 hours) decreases cell viability in NCI-H460 cells.
Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression.