Tangeretin,481-53-8

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YZ剂描述：

产品名称：Tangeretin

产品别名：桔皮素

英文别名：Tangeritin;NSC53909;NSC618905

靶点：Notch-1

CAS：481-53-8

纯度：＞98%

外观：white to off-white powder

保存方法：Store at -20° C

描述：

Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor. 

溶解性：DMSO ：24 mg/mL (64.45 mM)

体外研究：

Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion.

体内研究：In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice.

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