Quercetin Dihydrate,6151-25-3

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产品名称：Quercetin Dihydrate

产品别名：二水槲皮素

英文别名：Quercetin Dihydrate

靶点：PI3Kγ；PI3Kβ；PI3Kδ

CAS：6151-25-3

纯度：98%

外观：Yellow solid

保存方法：Store at -20°C

描述：

Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. 

溶解性：DMSO : 62 mg/mL (183.3 mM)
Ethanol : 15 mg/mL (44.3 mM)

体外研究：

Quercetin (dihydrate) is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits[1]. Quercetin (dihydrate) is a PI3K inhibitor with IC50s of 2.4-5.4 μM. Quercetin dihydrate (Sophoretin dihydrate) strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin (dihydrate) inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.

体内研究：LD50:小鼠159毫克/千克(灌胃给药)

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