SB 203580,152121-47-6

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YZ剂描述：

产品名称：SB 203580

产品别名：RWJ 64809; PB 203580; SB203580; SB-203580

英文别名：RWJ 64809;PB 203580;SB203580;SB-203580

靶点：p38 MAPK ,PKB

CAS：152121-47-6

纯度：0.99

外观：Lyophilized powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

SB203580是一种p38 MAPKYZ剂，在THP-1细胞中IC50为0.3-0.5μM，对SAPK3(106T)和SAPK4(106T)选择性低10倍，且阻断PKB磷酸化，IC50为3-5μM。SB203580是个被报道的p38YZ剂。

溶解性：DMSO：43 mg/mL (113.92 mM)

体外研究：

SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.

体内研究：SB203580 protects pig myocardium against ischemic injury in an in vivo model. SB203580 is effective to prevent and treat the disease in MRL/lpr mice model of Systemic lupus erythematosus (SLE).

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