PIM-447 dihydrochloride,1820565-69-2

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产品名称：PIM-447 dihydrochloride

产品别名：LGH447 dihydrochloride

英文别名：LGH447 dihydrochloride

靶点：Pim

CAS：1820565-69-2

纯度：＞98%

外观：Powder

保存方法：Store at -20°C

描述：

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. target: pan-PIM inhibitor In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.

溶解性：DMSO : ≥ 46.7 mg/mL (90.97 mM)

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