分子量：
59216 Da
细胞定位：
Antigen Cellular Localization:Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:19126643}
形式：
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献：
Estrogen receptor ? exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib. Pinton G, Thomas W, Bellini P, Manente AG, Favoni RE, Harvey BJ, Mutti L, Moro L. PLoS One. 2010 Nov 29;5(11):e14110. PMID: 21124760
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Estrogen receptor beta (aa417-428) antibody (internal region).
功能：
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
总结：
This antibody is expected to recognize all reported isoforms (NP_001428.1; NP_001035365.1; NP_001201831.1; NP_001201832.1). Reported variants represent identical protein: NP_001035365.1, NP_001035366.1
联系方式：
生物商城：http://www.annoron.com
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官方售后：400-965-8633
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