阿米洛利盐酸盐水合物(2016-88-8)(≥98%)

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产品名称：阿米洛利盐酸盐水合物
英文名称：Amiloride hydrochloride hydrate
产品货号：L10078
产品规格：1g|5g
 属性

CAS号	2016-88-8
分子式	C6H8ClN7O.HCl
分子量	266.09
溶解性	Soluble in DMSO(25mg/ml),water(10mM warm),and methanol.Insoluble in chloroform,and ethanol.
存贮条件	储存温度-20℃

描述

应用	A calcium channel andsodium channel protein inhibitor
产品介绍	Amiloride?HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel(Polycystic kidney disease 2-like 1 protein:PKD2L1),a member of the transient receptor potential(TRP) superfamily of cation channels,including the NHE(sodium/hydgrogen exchanger).Amiloride is also an epithelial sodium channel protein inhibitor,which inhibits sodium reabsorption without affecting potassium concentrations.Amiloride serves as a non-selective acid-sensing ion channel(ASIC) blocker and a selective inhibitor of uPA(urokinase plasminogen activator).Research shows that amiloride reduces electrical potential across tubular epithelium,inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130μM.Amiloride?HCl is an inhibitor of Sodium/Potassium-ATPase Protein.
备注	Amiloride hydrochloride(Midamor),a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
生化机理	Selective T-type calcium channel blocker and blocker of epithelial sodium channel.Selective inhibitor of urokinase plasminogen activator(uPA).
别名	盐酸阿米洛利;N-脒基-3,5-二氨基-6-氯吡嗪甲酰胺盐酸盐;Midamor,Colectril,Amipramizide,Guanamprazine hydrochloride;1-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine hydrochloride

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