5-氮杂-2'-脱氧胞苷(2353-33-5)(98 %)
- 品牌:百奥莱博
- 型号:L10453-WNH
- 产地:北京
- 供应商:北京百奥莱博科技有限公司
- 供应商报价:¥380 - 3800
- 标签:5-氮杂-2'-脱氧胞苷(2353-33-5)(98 %)、5-氮杂-2'-脱氧胞苷(2353-33-5)(98 %)价格、5-氮杂-2'-脱氧胞苷(2353-33-5)(98 %)厂家、5-Aza-2′-deoxycytidine、、北京百奥莱博科技有限公司
特别提示:包括5-氮杂-2"-脱氧胞苷在内,本公司的所有产品仅可用于科研实验,严禁用于临床YL及其他非科研用途!
| CAS号 | 2353-33-5 |
| 分子式 | C8H12N4O4 |
| 分子量 | 228.21 |
| 产品介绍 | Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation(hypomethylation) and gene activation by remodeling "opening" chromatin.Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation(hypomethylation) and gene activation by remodeling "opening" chromatin.Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. |
| 生化机理 | 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation.DNA demethylation can regulate gene expression by "opening"the chromatin structure detectable as increased nuclease sensitivity.This remodeling of chromatin structure allows transcription factors to bind to the promoter regions,assembly of the transcription complex,and gene expression. |
| 别名 | 5-氮杂-2"-脱氧胞苷;5氮杂2脱氧胞嘧啶核苷;地西他滨;5-氮杂-1(2-脱氧-β-D-呋nán核糖基)胞嘧啶;2′-Deoxy-5-azacytidine4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-oneDecitabine |