产品货号 : jlcR6400 英文名称 : TFDP3 中文名称 :转录因子DP3/肝癌相关抗原661抗体 别 名 : Cancer/testis antigen 30; CT30; E2F-like; HCA661; Hepatocellular carcinoma-associated antigen 661; TFDP3; Transcription factor Dp family member 3; TFDP3_HUMAN. 研究领域 : 细胞生物 细胞周期蛋白 转录调节因子 表观遗传学 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 : 45kDa 细胞定位 : 细胞核 细胞浆 性 状 : Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from human TFDP3:301-405/405 亚 型 : IgG 纯化方法 : affinity purified by Protein A 储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
Subunit: Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent transcriptional activity.
Subcellular Location: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
Tissue Specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.
Similarity: Belongs to the E2F/DP family.
SWISS: Q5H9I0
Gene ID: 51270
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
