产品货号:jlcR17275 英文名称:SCC4 中文名称:同类型染色单体凝聚蛋白4抗体 别 名:K0892; KIAA0892; Mau 2; Mau 2L; mau-2; Mau2; SCC4_HUMAN; MAU2L; Scc 4; sister chromatid cohesion 4. 研究领域:细胞生物 免疫学 染色质和核信号 表观遗传学 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应:Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量:69kDa 细胞定位:细胞核 性 状:Lyophilized or Liquid 浓 度:1mg/ml 免 疫 原:KLH conjugated synthetic peptide derived from human SCC4:51-150/613 亚 型:IgG 纯化方法:affinity purified by Protein A 储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍:Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.
Function: Scc4 (Mau2) is the metazoan homologue of Scc4 in S. cerevisiae. In yeast, Scc4 binds to Scc2 to form an essential complex that loads cohesion onto chromosomes. Similarly, the Scc4 / Mau2 protein in metazoans plays a significant role in sister chromatid separation and in loading of cohesin onto chromatin. The Scc2-Scc4 complex is tethered to pre-replication complexes through the Cdc7-Drf1 protein kinase DDK.
Subunit: Interacts (via N-terminus) with NIPBL to form the cohesion loading complex.
Subcellular Location: Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase.
Similarity: Belongs to the SCC4/mau-2 family. Contains 4 TPR repeats.
SWISS: Q9Y6X3
Gene ID: 23383
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
