重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)

特别提示：包括重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！

产品名称：重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)
英文名称：Recombinant Human E3 Ubiquitin-Protein Ligase CHIP
产品货号：JN1919
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Tyr303表达纯化得来。

STUB1/CHIP质量控制：＞95%(还原性SDS-PAGE)

STUB1/CHIP制剂：液体

STUB1/CHIP保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于STUB1/CHIP：
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.

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