ABT-199(GDC-0199)(1257044-40-8)(≥99%)

特别提示：包括ABT-199(GDC-0199)在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！

产品名称：ABT-199(GDC-0199)
英文名称：ABT-199(GDC-0199)
产品货号：L10002
产品规格：25mg|5mg
 属性

CAS号	1257044-40-8
分子式	C45H50ClN7O7S
分子量	868.44
折光率	1.64
溶解性	Soluble in DMSO(100mg/ml(~115mM) at 25℃),water(<1 mg/ml(<1mM) at 25℃),and ethanol(<1 mg/ml(<1mM) at 25℃).
存贮条件	储存温度-20℃

描述

应用	A Bcl-2-selective inhibitor with Ki of<0.01 nM
产品介绍	ABT-199(GDC-0199)是GX的Bcl-2选择性YZ剂，Ki为0.01 nM，比对Bcl-xL和Bcl-w的YZ性高4800倍以上，对Mcl-1无活性。
备注	ABT-199(GDC-0199) is aBcl-2-selective inhibitor withKiof<0.01 nM,>4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Phase 2.
生化机理	ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2(BCL-2) family proteins,currently in clinical trials.ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets.A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24h.These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers.
别名	GDC-0199;GDC-0199;ABT199;ABT 199;GDC0199;GDC 0199;Venetoclax;abt 199;4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2,3-b)pyridin-5-yloxy)-benzamide

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