Recombinant Human FCGRT & B2M Heterodimer

公司供应的产品仅用于科研
产品名称：Recombinant Human FCGRT & B2M Heterodimer
Known as    IgG receptor FcRn;Neonatal Fc receptor;FCRN
Derived from    Human cells
Purity    Greater than 95% as determined by reducing SDS-PAGE.
Formulation    Lyophilized from a 0.2 μm filtered solution of 50mM HEPES,150mM Nacl,pH7.4.
Shipping    The product is shipped at ambient temperature.
Storage    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Reconstitution    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin    Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Background    FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
Recombinant Human IgG Fc fragment receptor transporter is produced by our Mammalian expression system and the target gene encoding Ala24-Leu290&Ile21-Met119 is expressed with a 6His tag at the C-terminus.
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