Cellular Apoptosis Susceptibility

【Molecular Wt.】110 kDa

【Description】Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin α re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin α and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin α is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;ICC;IF;IHC;FC

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】Recombinant protein

【Positive control】Mouse testis tissue, SiHa, SK-BR-3, PC-3M, LOVO, SH-SY5Y, human colon cancer tissue, LOVO.

【Conjugate】Non-conjugated

【Alternative names】CAS antibody
Cellular apoptosis susceptibility protein antibody
Chromosome segregation 1 (yeast homolog) like antibody
Chromosome segregation 1 Like antibody
Chromosome segregation 1 like protein antibody
Chromosome segregation 1-like protein antibody
Chromosome segregation gene CSE1 antibody
CSE 1 antibody
CSE 1 chromosome segregation 1 like antibody
CSE 1 chromosome segregation 1 like protein antibody
CSE 1L antibody
CSE1 antibody
CSE1 chromosome segregation 1 like (yeast) antibody
CSE1 chromosome segregation 1 like antibody
CSE1 chromosome segregation 1 like protein antibody
CSE1L antibody
Exp 2 antibody
Exp2 antibody
Exportin 2 antibody
Exportin-2 antibody
Exportin2 antibody
Importin alpha re exporter antibody
Importin-alpha re-exporter antibody
MGC117283 antibody
MGC130036 antibody
MGC130037 antibody
XPO 2 antibody
XPO2 antibody
XPO2_HUMAN antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Cytoplasm. Nucleus.

【Background References】1. Kutay U et al. Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061-1071 (1997).
2. Brinkmann U et al. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. Proc Natl Acad Sci USA 92:10427-10431 (1995).

【DatasheetURL】https://www.huabio.com/upload/ET7106-90.pdf

【Uniprot ID】P55060(Human) Q9ERK4(Mouse)

【Raised in】Rabbit

【Clone No.】JU34-33