重组人突触后密度蛋白95(PSD-95)(Dlg4)

特别提示：包括重组人突触后密度蛋白95(PSD-95)(Dlg4)在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！

产品名称：重组人突触后密度蛋白95(PSD-95)(Dlg4)
英文名称：Recombinant Human Postsynaptic Density Protein 95
产品货号：JN1181
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu724在N端含有His标签。

Dlg4质量控制：＞95%(还原性SDS-PAGE)

Dlg4制剂：冻干品

Dlg4保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Dlg4复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Dlg4：
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and1 SH3 domain.With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

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