Biotinylated Human B7-H3 / CD276 Protein, Avitag™,His Tag

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody// Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human B7-H3// Avitag//His Tag (Cat. No. B73-H82E6) with a linear range of 5-39 ng/mL (QC tested). Measured by its binding ability in a functional ELISA. Immobilized Biotinylated Human B7-H3// Avitag//His Tag (Cat. No. B73-H82E6) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate// can bind Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody// Human IgG1 with a linear range of 0.3-5 ng/mL (Routinely tested).

产品背景:
B7 homolog 3 (B7-H3)// a member of the immunoglobulin superfamily// is also known CD276// which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore// B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

产品描述:
This protein carries an Avi tag (Avitag™) at the C-terminus// followed by a polyhistidine tag. The protein has a calculated MW of 26.5 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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