| 品名 | anti- CSK antibody |
| 货号 | FNab02016 |
| 规格 | 100µg |
| 状态 | liquid |
| 纯化方法 | Immunogen affinity purified |
| 纯度 | ≥95% as determined by SDS-PAGE |
| 宿主 | Rabbit |
| 亚型 | IgG |
| 存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
| 背景介绍 | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
| 免疫原 | c-src tyrosine kinase |
| 别称 |
| 分子量 | 50 kDa |
| Uniprot ID | P41240 |
| 适用种属 | Human |
| 验证应用 | ELISA, WB, IHC, IF, IP |
| 建议稀释比例 |
| 图片 |  | Immunohistochemistry of paraffin-embedded human lung using FNab02016(CSK antibody) at dilution of 1:200 |
 | HL-60 cells were subjected to SDS PAGE followed by western blot with FNab02016(CSK antibody) at dilution of 1:800 |
| 注意事项 | CSK antibody|CSK抗体仅供科研使用 |
| 产品链接 | https://www.fn-test.cn/product/FNab02016/ |