品名 | anti- DIABLO antibody |
货号 | FNab02384 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO. |
免疫原 | diablo homolog(Drosophila) |
别称 | DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3 |
分子量 | 20 kDa |
Uniprot ID | Q9NR28 |
适用种属 | Human, Mouse, Rat |
验证应用 | ELISA, WB, IHC, IP |
建议稀释比例 | WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200 |
图片 |  | Immunohistochemistry of paraffin-embedded human testis using FNab02384(DIABLO antibody) at dilution of 1:50 |
 | HepG2 cells were subjected to SDS PAGE followed by western blot with FNab02384(DIABLO antibody) at dilution of 1:1000 |
注意事项 | DIABLO antibody|DIABLO抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab02384/ |