DGCR8 C-Terminal antibody|DGCR8 C-Terminal抗体

DGCR8 C-Terminal antibody|DGCR8 C-Terminal抗体具有高亲合力和高特异性深受国外市场认可；菲恩生物专注于免疫学、细胞生物学、肿瘤、神经生物学等领域。
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产品介绍

品名	anti- DGCR8 C-Terminal antibody
货号	FNab02351
规格	100µg
状态	liquid
纯化方法	Immunogen affinity purified
纯度	≥95% as determined by SDS-PAGE
宿主	Rabbit
亚型	IgG
存储	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.)
背景介绍	Component of the microprocessor complex that acts as a RNA-and heme-binding protein that is involved in the initial step of microRNA(miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts(pri-miRNAs) to release precursor miRNA(pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs(PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer(of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding(PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine(m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing(PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal(By similarity).
免疫原	DiGeorge syndrome critical region gene 8
别称	C22orf12, DGCR8, DGCRK6, Gy1
分子量	120 kDa
Uniprot ID	Q8WYQ5
适用种属	Human, Mouse, Rat
验证应用	ELISA, WB, IHC, IF, IP, FC
建议稀释比例	WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200
图片		Immunohistochemistry of paraffin-embedded human breast cancer using FNab02351(DGCR8 antibody) at dilution of 1:100
		HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab02351(DGCR8 antibody) at dilution of 1:1000
注意事项	DGCR8 C-Terminal antibody|DGCR8 C-Terminal抗体仅供科研使用
产品链接	https://www.fn-test.cn/product/FNab02351/

菲恩简介
  菲恩生物面向国际市场专业研发，生产和销售ELISA试剂盒、抗体、重组蛋白及相关试剂,主要应用于免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究。

菲恩生物位置
  菲恩生物坐落于高新区、生物产业基地--武汉光谷生物城（biolake）。

菲恩优势
  1、专业科研试剂生产商，具有独立的现代化研发ZX和GMP标准的生产车间，产品高质控，高纯度，高活性，成本更低，价格竞争力强。
  2、专业科研试剂的研发，专注于免疫学、细胞生物学、肿瘤、神经生物学等领域，每年新增研发产品千余种。产品数量、批间批内差、亲合力、特异性达国际标准，
菲恩生物—科研好帮手，专业生产商。

研究领域
  免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究

质量保证
  菲恩生物建有现代化的研发ZX和符合GMP标准的生产车间，整体通过ISO 9001:2015质量管理体系认证。

产品数量
  ELISA试剂盒：18个种属：人、大鼠、小鼠、猪、牛、其他稀有种属
  主要指标：
    1、细胞因子：IL、Selectin、CSF、TNF、IF、TGF、chemokine、CAM、IGF、CR等；
    2、心肌梗塞：cTn，MYO，CRP等；
    3、内分泌：TH、Pg、Testosterone、GH、Cytokine receptor、Endothelin、COR、BGP、PRL、ACTH、FSH、Estradiol等；
    4、肝纤维化：HA、MMP、LN等；
    5、肿瘤标志物：TNF、TNFSF10、TNFRSF1A等；
    6、特种蛋白：Ig、CRP、ALB、FE、TRF等。
  抗体：兔多抗、鼠单抗种类丰富，一抗1万余种，二抗100多种；
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