NR1D2 antibody|NR1D2抗体

NR1D2 antibody|NR1D2抗体具有高亲合力和高特异性深受国外市场认可；菲恩生物专注于免疫学、细胞生物学、肿瘤、神经生物学等领域。
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产品介绍

品名	anti- NR1D2 antibody
货号	FNab05833
规格	100µg
状态	liquid
纯化方法	Immunogen affinity purified
纯度	≥95% as determined by SDS-PAGE
宿主	Rabbit
亚型	IgG
存储	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.)
背景介绍	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence(RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides(RevDR-2). Acts as a potent competitive repressor of ROR alpha(RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs(eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1(SREBF1) and the inflammatory mediator interleukin-6(IL6) in the skeletal muscle.
免疫原	nuclear receptor subfamily 1, group D, member 2
别称
分子量	70 kDa
Uniprot ID	Q14995
适用种属	Human, Mouse, Rat
验证应用	ELISA, WB
建议稀释比例
图片
		HeLa cells were subjected to SDS PAGE followed by western blot with FNab05833( NR1D2 Antibody) at dilution of 1:300
注意事项	NR1D2 antibody|NR1D2抗体仅供科研使用
产品链接	https://www.fn-test.cn/product/FNab05833/

菲恩简介
  菲恩生物面向国际市场专业研发，生产和销售ELISA试剂盒、抗体、重组蛋白及相关试剂,主要应用于免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究。

菲恩生物位置
  菲恩生物坐落于高新区、生物产业基地--武汉光谷生物城（biolake）。

菲恩优势
  1、专业科研试剂生产商，具有独立的现代化研发ZX和GMP标准的生产车间，产品高质控，高纯度，高活性，成本更低，价格竞争力强。
  2、专业科研试剂的研发，专注于免疫学、细胞生物学、肿瘤、神经生物学等领域，每年新增研发产品千余种。产品数量、批间批内差、亲合力、特异性达国际标准，
菲恩生物—科研好帮手，专业生产商。

研究领域
  免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究

质量保证
  菲恩生物建有现代化的研发ZX和符合GMP标准的生产车间，整体通过ISO 9001:2015质量管理体系认证。

产品数量
  ELISA试剂盒：18个种属：人、大鼠、小鼠、猪、牛、其他稀有种属
  主要指标：
    1、细胞因子：IL、Selectin、CSF、TNF、IF、TGF、chemokine、CAM、IGF、CR等；
    2、心肌梗塞：cTn，MYO，CRP等；
    3、内分泌：TH、Pg、Testosterone、GH、Cytokine receptor、Endothelin、COR、BGP、PRL、ACTH、FSH、Estradiol等；
    4、肝纤维化：HA、MMP、LN等；
    5、肿瘤标志物：TNF、TNFSF10、TNFRSF1A等；
    6、特种蛋白：Ig、CRP、ALB、FE、TRF等。
  抗体：兔多抗、鼠单抗种类丰富，一抗1万余种，二抗100多种；
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