品名 | anti- TRIM24 antibody |
货号 | FNab08975 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity). |
免疫原 | tripartite motif-containing 24 |
别称 | HTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1, TIF1 alpha, TIF1A, TIF1ALPHA, TRIM24, tripartite motif containing 24 |
分子量 | 64 kDa |
Uniprot ID | O15164 |
适用种属 | Human, Mouse, Rat |
验证应用 | ELISA, WB, IHC, IP |
建议稀释比例 | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500 |
图片 |  | Immunohistochemistry of paraffin-embedded human prostate cancer using FNab08975(TRIM24 antibody) at dilution of 1:100 |
 | HeLa cells were subjected to SDS PAGE followed by western blot with FNab08975(TRIM24 antibody) at dilution of 1:500 |
注意事项 | TRIM24 antibody|TRIM24抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab08975/ |