品名 | anti- NUMBL antibody |
货号 | FNab05918 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Protein A+G purification |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Mouse |
亚型 | IgG2a |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
免疫原 | numb homolog(Drosophila)-like |
别称 |
分子量 | 70 kDa |
Uniprot ID | Q9Y6R0 |
适用种属 | Human |
验证应用 | ELISA, WB, IHC |
建议稀释比例 | WB: 1:500-1:2000; IHC: 1:20-1:200 |
图片 |  | Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab05918(NUMBLIKE Antibody) at dilution of 1:50 |
 | L02 cells were subjected to SDS PAGE followed by western blot with FNab05918(NUMBLIKE Antibody) at dilution of 1:1000 |
注意事项 | NUMBL antibody|NUMBL抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab05918/ |