BAPTA-AM,1,2-双(2-氧基)乙烷-N,N,N,N-四乙酸四(乙酰氧基甲酯),126150-97-8

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试剂描述：

产品名称：BAPTA-AM

产品别名：1,2-双(2-氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯;胞内钙荧光探针BAPTA-AM;1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester);Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate

CAS号：126150-97-8

英文别名：N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)methyl] Ester; BAPTA-AM;1,2-Bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic Acid Tetraacetoxymethyl Ester;

分子量：764.68

分子式：C₃₄H₄₀N₂O₁₈

纯度：0.95

外观：White to Off-White Solid

保存方法：Hygroscopic, -20˚C Freezer, Under Inert Atmosphere

描述：

BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research.

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