AZD8055(≥99%)北京现货
- 品牌：百奥莱博
- 型号：L10089-XTJ
- 产地：北京
- 供应商：北京百奥莱博科技有限公司
- 供应商报价：¥380 - 3800
- 标签：AZD8055(≥99%)北京现货、AZD8055(≥99%)北京现货价格、AZD8055(≥99%)北京现货厂家、AZD8055、、北京百奥莱博科技有限公司
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特别提示：包括AZD8055在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！
| CAS号 | 1009298-09-2 |
| 分子式 | C25H31N5O4 |
| 分子量 | 465.56 |
| 溶解性 | DMSO ≥90mg/mL Water ≥1.8mg/mL Ethanol ≥13mg/mL |
| 存贮条件 | 储存温度-20℃ |
| 密度 | 1.2480 |
| 产品介绍 | AZD8055是ATP竞争性mTORYZ剂，IC50为0.8 nM，比对PI3K和ATM/DNA-PK的YZ性强超过1000倍。 |
| 备注 | AZD8055 is a novel ATP-competitivemTORinhibitor withIC50of 0.8 nM with excellent selectivity(?1,000-fold) against PI3K isoforms and ATM/DNA-PK.Phase 1. |
| 生化机理 | AZD8055 shows low activity(～1,000-fold) against all PI3K isoforms(α,β,γ,δ) and other members of the PI3K-like kinase family(ATM and DNA-PK).AZD8055 inhibits the phosphorylation of mTORC1(p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2(Akt) and downstream proteins.The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055,resulting in significant inhibition of cap-dependent translation.AZD8055 potently inhibits proliferation in U87MG,A549 and H838 cells with IC50 of 53,50 and 20 nM,respectively.AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells[1].AZD8055 decreases AML blast cell proliferation and cell cycle progression,reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells |
| 别名 | (5-(2,4-二((3S)-3-甲基mǎ啉-4-基)bǐ啶并(2,3-d)嘧啶-7-基)-2-jiǎ氧基苯基)jiǎ醇;;AZD8055;AZD 8055;(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol |
