ABT-199(GDC-0199)(≥99%)北京厂家
- 品牌：百奥莱博
- 型号：L10002-LHJ
- 产地：北京
- 供应商：北京百奥莱博科技有限公司
- 供应商报价：¥380 - 3800
- 标签：ABT-199(GDC-0199)(≥99%)北京厂家、ABT-199(GDC-0199)(≥99%)北京厂家价格、ABT-199(GDC-0199)(≥99%)北京厂家厂家、ABT-199(GDC-0199)、、北京百奥莱博科技有限公司
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特别提示：包括ABT-199(GDC-0199)在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！
| CAS号 | 1257044-40-8 |
| 分子式 | C45H50ClN7O7S |
| 分子量 | 868.44 |
| 折光率 | 1.64 |
| 溶解性 | Soluble in DMSO(100mg/ml(~115mM) at 25℃),water(<1 mg/ml(<1mM) at 25℃),and ethanol(<1 mg/ml(<1mM) at 25℃). |
| 存贮条件 | 储存温度-20℃ |
| 应用 | A Bcl-2-selective inhibitor with Ki of<0.01 nM |
| 产品介绍 | ABT-199(GDC-0199)是GX的Bcl-2选择性YZ剂，Ki为0.01 nM，比对Bcl-xL和Bcl-w的YZ性高4800倍以上，对Mcl-1无活性。 |
| 备注 | ABT-199(GDC-0199) is aBcl-2-selective inhibitor withKiof<0.01 nM,>4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Phase 2. |
| 生化机理 | ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2(BCL-2) family proteins,currently in clinical trials.ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets.A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24h.These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers. |
| 别名 | GDC-0199;GDC-0199;ABT199;ABT 199;GDC0199;GDC 0199;Venetoclax;abt 199;4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2,3-b)pyridin-5-yloxy)-benzamide |
