重组人alpha突触核蛋白A30P/A53T

产品英文名称：
Recombinant Human Alpha-Synuclein A53T

英文简称:
SNCA A53T

中文名称:
重组人alpha突触核蛋白 A53T

背景资料:
a-Synuclein （amino acids 1-140）， an acidic neuronal protein of 140 amino acids， is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has bA-Synuclein A53T Human Recombinant which is a Parkinson’s disease-related point mutant， produced in E.Coli is a single， non-glycosylated polypeptide chain of 140 amino acids having a molecular mass of 14.4kDa （molecular size on SDS-PAGE will appear higher）. The Recombinant Human a-Synuclein A53T is purified by proprietary chromatographic techniques.n suMDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEAested to be implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders， and more recently， to be an important regulatory component of vesicular transport in neuronal cells. Moreover， recent studies have shown that a-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail （amino acids 96-140）.

产品描述:
A-Synuclein A53T Human Recombinant which is a Parkinson’s disease-related point mutant， produced in E.Coli is a single， non-glycosylated polypeptide chain of 140 amino acids having a molecular mass of 14.4kDa （molecular size on SDS-PAGE will appear higher）. The Recombinant Human a-Synuclein A53T is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

溶解建议:
提供的重组人alpha突触核蛋白 A53T产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人alpha突触核蛋白 A53T产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.产品若长期保存，建议添加载体蛋白（0.1% HSA或BSA）.避免反复冻融.
其他简介：

  ProSpec是一家细胞因子蛋白及相关抗体生产和研发品Pai。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种Z多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。