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(±)-Methoxyverapamil (hydrochloride)

产品信息
  • 规格:5mg产品价格:300
    规格:10mg产品价格:520
    规格:25mg产品价格:970
    规格:50mg产品价格:1360
    Catalog Number GC18603
    Synonyms N/A
    Molecular Formula C28H40N2O5.HCl
    Relative Molecular Mass 521.1
    CAS Registry Number 16662-46-7
    Formulation A solid
    Purity ≥98%
    Storage Store at -20°C
    SMILES COC1=C(OC)C=C(C(C(C)C)(C#N)CCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC.Cl
    产品描述
    (±)-Methoxyverapamil is a phenylalkylamine L-type calcium channel blocker and methoxy derivative of verapamil . (±)-Methoxyverapamil blocks recombinant rat L-type calcium channels expressed in tsA201 cells with IC50 values of 782 and 8,000 nM at holding potentials of 10 and -60 mV, respectively. It blocks maitotoxin-induced calcium influx in NIH3T3 fibroblasts (IC50 = 16 μM) and inhibits histamine-induced acid secretion by primary enriched guinea pig parietal cells (IC50 = 10.9 μM). (±)-Methoxyverapamil binds to rat myocardial membranes (IC50 = 16 nM) and inhibits electrically-stimulated contractions in rat right myocardial ventricular strips (EC50 = 1.95 μM). In conscious, ovariectomized, post-partum rats, it decreases blood pressure by 30 mm Hg and induces 60% inhibition of uterine contractions when administered at doses of 204 and 324 μg/kg, respectively.
    更多产品信息,请点击:https://www.glpbio.cn/search.php?catalog=GC18603
    原装进口,(±)-Methoxyverapamil (hydrochloride),美国GlpBio品Pai大包装更优惠!
    美国Glpbio是一家领先的小分子YZ剂、激活剂、化合物库、多肽和实验室试剂的供应商。公司经营范围广泛,产品涉及癌症、免疫学、神经科学、细胞凋亡、表观遗传学等20多个不同研究领域,拥有10000多种产品。总部位于美国加利福尼亚,营销网点遍及法国、德国、加拿大、日本、澳大利亚、新加坡、以色列等20多个国家地区,竭诚为各国的科研工作者提供优质的产品和专业的服务。

    温馨提示:不可用于临床ZL。
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